The Western Highway is closed in both directions between Horsham and Dimboola following a serious overnight collision.
Diversions have been set up with drivers advised to use Blue Ribbon Road and Borung Highway as an alternative, adding an extra 15 minutes to the journey.
The incident is under control of emergency services and the highway will open once investigations have been completed and is safe to do so. Expect the closure to be in place until early afternoon today.
For the latest traffic information around the state visit traffic.vicroads.vic.gov.au or download the VicTraffic app via your app store.